22. Standard operating procedure for personalized cancer vaccine designs

Recent efforts to design personalized cancer immunotherapies use predicted neoantigens. To create a personalized cancer vaccine, strong-binding neoantigenic peptides are computationally predicted from matched tumor-normal sequencing data, and then ranked according to their predicted capability in stimulating a T cell response. These neoantigenic peptides arise due to various changes in the somatic genome and identification and characterization of these neoantigens is a critical step in designing these treatment regimens.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research