26. Community engagement for crowd-sourcing clinically relevant somatic variants, the CIViC experience.
The crowd-sourced, public domain knowledgebase CIViC (Clinical Interpretations of Variants in Cancer; civicdb.org) is composed of literature-derived evidence for the clinical utility of cancer variants. Evidence is captured in CIViC using concepts from established ontologies and CIViC-defined descriptive fields alongside human-readable text. This structured data allows for complex searches, programmatic access, and rapid integration into other resources. Anyone can curate evidence for CIViC by creating a login.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Kilannin Krysiak, Arpad Danos, Alex Wagner, Joshua McMichael, Adam Coffman, Susanna Kiwala, Nick Spies, Lynzey Kujan, Erica Barnell, Lana Sheta, Shahil Pema, Kaitlin Clark, Jason Saliba, Yang-Yang Feng, Benjamin Ainscough, Zach Skidmore, Cody Ramirez, Mal Source Type: research