37. Spatiotemporal patterns of metastatic spread and survival from MSK-IMPACT, a large-scale prospective clinical sequencing

Most large public cancer genomics datasets are focused on non-metastatic disease or lack information about spatiotemporal patterns of metastatic spread and survival. We have developed new clinical data extraction methods and performed an integrative analysis of clinical and genomic features from 34,836 patients treated at Memorial Sloan Kettering Cancer Center (MSK), stratified into 45 cancer subtypes. Tumors and matched normal were sequenced with MSK-IMPACT, a targeted next-generation sequencing assay that identifies genomic alterations in 468 genes.

Source: Cancer Genetics and Cytogenetics - May 31, 2020 Category: Genetics & Stem Cells Authors: Bastien Nguyen, Christopher Fong, Francisco Sanchez Vega, Anisha Luthra, Subhiksha Nandakumar, Henry Walch, Walid Chatila, Arjun Raj Rajanna, Renzo Dinatale, David Solit, Michael Berger, Ahmet Zehir, Jianjiong Gao, Nikolaus Schultz Source Type: research