38. Comparative molecular genomic analyses of a Rhesus Lynch Syndrome model

Colorectal cancer (CRC) is the third most common cancer in the U.S. Most CRC is sporadic, but Lynch Syndrome (LS) is the most common hereditary cancer syndrome predisposing to CRC and involves mismatch repair (MMR) deficiency. LS is secondary to germline mutations in one of four MMR genes (MLH1, MSH2, MSH6, and PMS2). Genetically engineered mouse models carrying germline mutations in MMR genes have significantly contributed to current understanding, but do not recapitulate the disease phenotype in LS patients and tissue-specific mouse models only do so partially.

Source: Cancer Genetics and Cytogenetics - May 31, 2020 Category: Genetics & Stem Cells Authors: Nejla Ozirmak Lermi, Stanton Gray, Muthuswamy Raveendran, Beth Dray, Ronald Harris, Fernando Benavides, Christian Abee, Jeffrey Rogers, Eduardo Vilar Source Type: research