Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging

Cystic fibrosis (CF) is an autosomal recessive disorder, affecting over 72,000 people worldwide [1 –3]. The mutation with the highest prevalence is p.Phe508del and between 85 and 90% of CF patients have at least one copy of this gene mutation [2,3]. The mutation leads to a dysfunctional CF transmembrane conductance regulator (CFTR) protein which disrupts the passage of chloride ions and bicarbo nate, causing increased viscosity of epithelial mucus. CFTR is expressed on many epithelia; including the gastrointestinal mucosa [1].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research