Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging
Cystic fibrosis (CF) is an autosomal recessive disorder, affecting over 72,000 people worldwide [1 –3]. The mutation with the highest prevalence is p.Phe508del and between 85 and 90% of CF patients have at least one copy of this gene mutation [2,3]. The mutation leads to a dysfunctional CF transmembrane conductance regulator (CFTR) protein which disrupts the passage of chloride ions and bicarbo nate, causing increased viscosity of epithelial mucus. CFTR is expressed on many epithelia; including the gastrointestinal mucosa [1].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Christabella Ng, Neele S. Dellschaft, Caroline L. Hoad, Luca Marciani, Lu Ban, Andrew P. Prayle, Helen L. Barr, Anke Jaudszus, Jochen G. Mainz, Robin C. Spiller, Penny Gowland, Giles Major, Alan R. Smyth Tags: Original Article Source Type: research
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