632 UVB induced EMT-like phenotype in keratinocytes is mediated by TLR3 activation

Risk factors for non-melanoma skin cancer (NMSC) include UVB exposure, genetic mutations, immunosuppression, and chronic inflammation. Activation of Toll-Like-Receptor 3 (TLR3), which recognizes dsRNA, leads to downstream activation of NF- κB and an upregulation of inflammatory cytokines. TLR3 protein expression is higher in moderately differentiated squamous cell carcinomas (SCCs) and infiltrative basal cell carcinomas (BCCs) compared to well-differentiated SCCs by immunohistochemistry (n> 6) suggesting TLR3 expression correlates with more aggressive NMSCs.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Photobiology Source Type: research