710 Vitiligo clinical and lesional molecular features associated with favorable response to NBUVB combined with topical tacrolimus

Vitiligo is an autoimmune disease resulting in death of melanocytes, causing disfiguring loss of skin pigmentation. It is known that numerous differentially expressed genes (DEGs) are present in vitiligo lesional skin. However, it is unknown if vitiligo DEGs are correlated with meaningful clinical characteristics, such as disease severity, duration and therapeutic response. The purpose of this study is to evaluate the clinical correlates of vitiligo DEGs. Thirty seven vitiligo patients were recruited for this study, each consented to skin biopsies from lesional as well as non-lesional skin.

Source: Journal of Investigative Dermatology - June 17, 2020 Category: Dermatology Authors: Q. Yang, J. Xu, M. Su, G. Zhang, X. Zhang, H. Lui, P. Zhou, Y. Zhou Tags: Pigmentation and Melanoma Source Type: research