727 Keloids are associated with Th2, JAK3, and CCR9/CCL25 inflammation

Keloids occur due to disturbed wound healing and abnormal collagen production, often affecting African American (AA) and Asian populations. An increased prevalence of atopic conditions, particularly asthma, has been described in keloid patients. However, its immune pathomechanism has not been studied, inhibiting therapeutic development. To evaluate the inflammatory signature of keloids in skin we obtained lesional and nonlesional biopsies from 3 AA patients with new onset keloids and 5 AA healthy controls.

Source: Journal of Investigative Dermatology - June 17, 2020 Category: Dermatology Authors: J. Wu, E. Del Duca, M. Espino, A. Diaz, N. Zhang, A. Gontzes, Y. Estrada, J.G. Krueger, A. Pavel, E. Guttman-Yassky Tags: Skin of Color Source Type: research