Association between Use of Angiotensin-converting Enzyme Inhibitors or Angiotensin Receptor Blockers and Postoperative Delirium

Conclusions Preoperative use of angiotensin system inhibitors is not associated with reduced postoperative delirium. In contrast, treatment during intensive care was associated with lower odds of delirium. Randomized trials of postoperative angiotensin-converting enzymes inhibitors and angiotensin receptor blockers seem justified.Editor ’s PerspectiveWhat We Already Know about This TopicPostoperative delirium is common in surgical intensive care patientsAngiotensin-converting enzyme inhibitors and angiotensin receptor blockers improve cognitive functionWhat This Article Tells Us That Is NewIn a single-center cohort study of adults admitted to a surgical intensive care unit, preoperative use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers was not associated with reduced postoperative deliriumHowever, rapidly starting angiotensin-converting enzyme inhibitors or angiotensin receptor blockers postoperatively was associated with reduced delirium
Source: Anesthesiology - Category: Anesthesiology Source Type: research