Up-regulation of Matrix Metalloproteinase-2 by Scleral Monocyte-derived Macrophages Contributes to Myopia Development

Myopia is a leading cause of visual impairment worldwide. This sight compromising condition is associated with scleral thinning, extracellular matrix (ECM) remodeling and inappropriate optical axial length elongation. Even though macrophages are present in the sclera, their involvement in this condition is unknown. By using a form-deprivation myopia (FDM) mouse model, we found that both the scleral macrophage density and their matrix metallopeptidase-2 (MMP-2) expression levels rose in myopic eyes.

Source: American Journal of Pathology - June 14, 2020 Category: Pathology Authors: Fei Zhao, Hao Wu, Peter S. Reinach, Yi Wu, Ying Zhai, Yi Lei, Li Ma, Yongchao Su, Yizhong Chen, Fen Li, Xing Liu, Nethrajeith Srinivasalu, Jia Qu, Xiangtian Zhou Source Type: research