Genetic Risk of Diverticular Disease Predicts Early Stoppage of Nicorandil.

This study aimed to identify diverticular disease genetic risk scores associated with early nicorandil stoppage, a surrogate marker for drug intolerance. A case-control study was carried out on 1,077 patients from the Genetics of Diabetes Audit and Research Tayside Scotland (GoDARTS) database. Cases were defined as having < 9 nicorandil prescriptions with no identifiable reason for stopping (n=230). Controls had either ≥ 9 prescriptions, treatment continuation to death/study end or stoppage post myocardial infarction. Two diverticular genetic risk scores were created and used in logistic regression models. Isosorbide mononitrate was used as a control analysis. Patients with a raised diverticular genetic risk score, based on 23 replicable loci, had increased risk of stopping nicorandil therapy early (univariate [OR 2.26 p=0.04], multivariate [OR 3.96 p=0.01]). Similar trends were noted when using the full 42 variant diverticular score but statistical significance was not reached. The isosorbide control analysis did not reach statistical significance. Our analysis demonstrates a novel positive association between a raised diverticular genetic risk score and early stoppage of nicorandil therapy. PMID: 32535905 [PubMed - as supplied by publisher]
Source: Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Pharmacol Ther Source Type: research