Role of gut microbiota in the GBR12909 model of mania-like behavior in mice

Growing evidence suggests a role for brain-gut-microbiota axis in affective disorders including major depression and bipolar disorder (BD). Herein, we aim to explore, by employing germ-free (GF) mice, the effect of the indigenous microbiota in the development of mania-like behavior. Conventional and GF mice were evaluated for the hyperlocomotion induced by the dopamine transporter inhibitor GBR12909 (15  mg/Kg), a validated model for mania-like behavior. Inflammatory mediators and neurotrophic factors were quantified in the prefrontal cortex, hippocampus and striatum.

Source: Journal of Neuroimmunology - June 15, 2020 Category: Allergy & Immunology Authors: Aline Silva de Miranda, Érica Leandro Marciano Vieira, Juliana dos Reis Bastos, Rodrigo Novaes Ferreira, Jacques R. Nicoli, Mauro Martins Teixeira, Leda Quercia Vieira, Fabrício A. Moreira, Antônio Lúcio Teixeira Source Type: research