The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice

Alcohol-associated liver disease is accompanied by dysregulation of bile acid metabolism and gut barrier dysfunction. Peroxisome proliferator-activated receptor-delta (PPAR δ) agonists are key metabolic regulators and have anti-inflammatory properties. Here, we evaluated the effect of the selective PPAR-delta agonist seladelpar (MBX‐8025) on gut barrier function and bile acid metabolism in a mouse model of ethanol-induced liver disease. Wild type C57BL/6 mice were f ed Lieber DeCarli diet containing 0% to 36% ethanol (caloric) for 8 weeks followed by a single binge of ethanol (5g/kg).

Source: Translational Research - June 14, 2020 Category: Research Authors: Huikuan Chu, Lu Jiang, Bei Gao, Nagsen Gautam, Jawaher A. Alamoudi, Sonja Lang, Yanhan Wang, Yi Duan, Yazen Alnouti, Edward E. Cable, Bernd Schnabl Source Type: research