MicroRNA-183 exerts a protective role in lupus nephritis through blunting the activation of TGF- β/Smad/TLR3 pathway via reducing Tgfbr1.

CONCLUSION: miR-183 inhibited the expression of Tgfbr1 by direct targeting to disrupt the TGF-β/Smad/TLR3 pathway, thus repressing renal fibrosis and the secretion of inflammatory factors in LN. PMID: 32535034 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32535034?dopt=Abstract

Source: Experimental Cell Research - June 10, 2020 Category: Cytology Authors: Qi H, Cao Q, Liu Q Tags: Exp Cell Res Source Type: research