MiR-30e-5p is sponged by Kcnq1ot1 and represses Angiotensin II-induced hypertrophic phenotypes in cardiomyocytes by targeting ADAM9.

In conclusion, Kcnq1ot1 sequestered miR-30e-5p to release ADAM9 to facilitate cardiac hypertrophy, indicating that Kcnq1ot1 might be used as a potentially therapeutic target for cardiac hypertrophy. PMID: 32535037 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32535037?dopt=Abstract

Source: Experimental Cell Research - June 10, 2020 Category: Cytology Authors: Wang W, Wu C, Ren L, Bao Y, Han Y, Li C, Li Y Tags: Exp Cell Res Source Type: research