Who's in control? Regulation of metabolism and pathogenesis in space and time.

Who's in control? Regulation of metabolism and pathogenesis in space and time.
Curr Opin Microbiol. 2020 Jun 09;:
Authors: King AN, de Mets F, Brinsmade SR
Abstract
Bacterial pathogens need to sense and respond to their environments during infection to align cell metabolism and virulence factor production to survive and battle host defenses. Complex regulatory networks including ligand-binding transcription factors, two-component systems, RNA-binding proteins, and small non-coding regulatory RNAs adjust gene expression programs in response to changes in metabolic fluxes, environmental cues, and nutrient availability. Recent studies underlined that these different layers of regulation occur along varying spatial and temporal scales, leading to changes in cell behavior and heterogeneity among the bacterial community. This brief review will highlight current research emphasizing that cell metabolism and pathogenesis are inextricably intertwined in both Gram-positive and Gram-negative bacteria.
PMID: 32532689 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - June 8, 2020 Category: Microbiology Authors: King AN, de Mets F, Brinsmade SR Tags: Curr Opin Microbiol Source Type: research