Bempedoic acid for the treatment of hypercholesterolemia.
Bempedoic acid for the treatment of hypercholesterolemia.
Expert Rev Cardiovasc Ther. 2020 Jun 12;:
Authors: Yang J
Abstract
INTRODUCTION: Although several lipid-lowering drugs are available, they are not sufficient for some patients. Bempedoic acid is a small molecule adenosine triphosphate citrate lyase inhibitor indicated for the treatment of adults with hypercholesterolemia.
AREAS COVERED: We performed a systematic review of the literature using PubMed database, and the following keywords were used: "bempedoic acid", "hypercholesterolemia", and "adenosine triphosphate citrate lyase" . The chemical property, mechanism of action, pharmacokinetics, clinical efficacy, and safety of bempedoic acid is introduced in this paper.
EXPERT OPINION: Bempedoic acid can modulate metabolism of cholesterol. Clinical trials indicated that bempedoic acid could significantly reduce low-density lipoprotein cholesterol levels. Bempedoic acid was well tolerated.
PMID: 32532162 [PubMed - as supplied by publisher]
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
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