Bempedoic acid for the treatment of hypercholesterolemia.

Bempedoic acid for the treatment of hypercholesterolemia. Expert Rev Cardiovasc Ther. 2020 Jun 12;: Authors: Yang J Abstract INTRODUCTION: Although several lipid-lowering drugs are available, they are not sufficient for some patients. Bempedoic acid is a small molecule adenosine triphosphate citrate lyase inhibitor indicated for the treatment of adults with hypercholesterolemia. AREAS COVERED: We performed a systematic review of the literature using PubMed database, and the following keywords were used: "bempedoic acid", "hypercholesterolemia", and "adenosine triphosphate citrate lyase" . The chemical property, mechanism of action, pharmacokinetics, clinical efficacy, and safety of bempedoic acid is introduced in this paper. EXPERT OPINION: Bempedoic acid can modulate metabolism of cholesterol. Clinical trials indicated that bempedoic acid could significantly reduce low-density lipoprotein cholesterol levels. Bempedoic acid was well tolerated. PMID: 32532162 [PubMed - as supplied by publisher]
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research