Limited efficacy of rapamycin monotherapy in vascularized composite allotransplantation.

CONCLUSIONS: We demonstrate that while RPM increased the ratio of Treg to Teff cells and suppressed CD8+ T cell allo-activation, it failed to prevent CD4 Teff cell activation and impaired CXCR3-dependent Treg graft homing, thereby limiting the efficacy of RPM in VCA recipients.
PMID: 32535143 [PubMed - as supplied by publisher]

Source: Transplant Immunology - June 10, 2020 Category: Transplant Surgery Authors: Xu H, Steinberger Z, Wang L, Han R, Zhang Y, Hancock WW, Levin LS Tags: Transpl Immunol Source Type: research