Volume-dependent dose-response of the intestinal stem cell niche and lymphoid tissue.

CONCLUSION: Our findings present the first observation of a field-size dependent dose-response of the intestinal stem cell niche. Its regeneration process does apparently not rely on distant radiation-sensitive resources of the organism, such as the bone marrow. Yet, our observations suggest that the niche interacts with intact tissue in millimetres distance, leading to faster crypt regeneration. The field-size dependent dose-response of SILTs posits a role of the immune system on the dose-volume effect. PMID: 32534012 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32534012?dopt=Abstract

Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 9, 2020 Category: Radiology Authors: Bahn E, van Heerden M, Sachse KN, Gueulette J, Slabbert JP, Alber M, Shaw W Tags: Radiother Oncol Source Type: research