Downregulating the P2 × 3 Receptor in the Carotid Body to Reduce Blood Pressure via Acoustic Gene Delivery in Canines
The purinergic P2 × 3 receptor in the carotid body (CB) is considered a new target for treating hypertension, although approaches for targeted regulating P2 × 3 receptor expression are lacking. Here, we explored the feasibility of targeted P2 × 3 receptor down-regulation in CBs by localized low-intens ity focused ultrasound (LIFU)-mediated gene delivery to reduce the blood pressure. Thirty-two Kunming canines were randomly assigned to the treatment group (n = 14), negative control group (n = 10), LIFU + cationic microbubbles group (n = 4), and LIFU-only group (n = 4).
Source: Translational Research - Category: Research Authors: Qian Xue, Ruiyu Wang, Liang Wang, Bo Xiong, Lingjiao Li, Jun Qian, Lan Hao, Zhigang Wang, Dichuan Liu, Changming Deng, Shunkang Rong, Yuanqing Yao, Yonghong Jiang, Que Zhu, Jing Huang Source Type: research