The fungal airway microbiome in cystic fibrosis and non-cystic fibrosis bronchiectasis

Cystic fibrosis (CF) and non-CF bronchiectasis are chronic suppurative lung diseases characterised by permanent bronchial dilatation, variable mucociliary clearance and recurrent infections [1,2]. Recent culture-independent studies have illustrated a far more complex bacterial airway biodiversity than revealed by conventional microbiology [3]. By contrast the extent of fungal infection of the airways is much less clear, and the prevalence and clinical significance of fungal communities in sputum is comparatively poorly understood [4,5].

Source: Journal of Cystic Fibrosis - June 12, 2020 Category: Respiratory Medicine Authors: Leah Cuthbertson, Imogen Felton, Phillip James, Michael J. Cox, Diana Bilton, Silke Schelenz, Michael R. Loebinger, William O.C. Cookson, Nicholas J. Simmonds, Miriam F. Moffatt Source Type: research