Loss of PTEN sensitizes head and neck squamous cell carcinoma to 5-AZA-2 ’-deoxycytidine

In this study, we investigated the effect of the DNA demethylation agent 5-AZA-2 ’-deoxycytidine (5-AZA) over HNSCC and its population of cancer stem cells (CSCs) presenting dysfunctional PTEN.

Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - June 12, 2020 Category: ENT & OMF Authors: Gabriell Bonifacio Borgato, Gabriel Alvares Borges, Ana Paula Souza, Cristiane Helena Squarize, Rogerio Moraes Castilho Source Type: research