Lung and eye disease develop concurrently in supplemental oxygen-exposed neonatal mice.

Lung and eye disease develop concurrently in supplemental oxygen-exposed neonatal mice. Am J Pathol. 2020 Jun 08;: Authors: Wickramasinghe LC, Lau M, Deliyanti D, Gottschalk TA, van Wijngaarden P, Talia D, Johnson C, Wilkinson-Berka JL, Tsantikos E, Hibbs ML Abstract Bronchopulmonary dysplasia and retinopathy of prematurity are two debilitating disorders that develop in preterm infants exposed to supplemental oxygen to prevent respiratory failure. Both can lead to lifelong disabilities such as chronic obstructive pulmonary disease and vision loss. Due to the lack of a standard experimental model of coincident disease, the underlying associations between BPD and ROP are not well characterized. To address this gap, the robust mouse model of oxygen-induced retinopathy was employed exposing C57BL/6 mice to 75% oxygen from postnatal day (PN) 7 to 12. The cardinal features of ROP were replicated by this strategy and the lungs of the same mice were simultaneously examined for evidence of BPD-like lung injury, investigating both the short and long-term effects of early-life supplemental oxygen exposure. At PN12 and PN18, mild lung disease was evident by histopathology together with the expected vasculopathy in the inner retina. At later time-points, the lung lesion had progressed to severe airspace enlargement and alveolar simplification, with concurrent thinning in the outer layer of the retina. In addition, critical angiogenic, oxidative s...
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research