Sex ‐dependent alterations of dopamine receptor and glucose transporter density in rat hypothalamus under long‐term clozapine and haloperidol medication

ConclusionClozapine sex ‐dependently affects the expression of D2R, Glut1, and Glut3. The upregulation of the glucose transporters indicates glucose deprivation in the endothelial cells and consequently in astrocytes and neurons. Increased hypothalamic lactate in females under clozapine points to enhanced glycolysis with a higher glucose demand to produce the required energy. Haloperidol did not change the expression of the glucose transporters and upregulated D2R only in males.

Source: Brain and Behavior - June 10, 2020 Category: Neurology Authors: Marie ‐Luise Bouvier, Karin Fehsel, Andrea Schmitt, Eva Meisenzahl‐Lechner, Wolfgang Gaebel, Martina Wilmsdorff Tags: ORIGINAL RESEARCH Source Type: research