Pharmacokinetics of ASP4345 from Single Ascending-Dose and Multiple Ascending-Dose Phase I Studies

ConclusionsThe pharmacokinetics of ASP4345 suggest that single daily dosing is appropriate for ASP4345. Furthermore, the concentration of ASP4345 in cerebrospinal fluid compared to free drug concentrations in plasma provides evidence of penetration of ASP4345 into the brain.

http://link.springer.com/10.1007/s40262-020-00911-0

Source: Clinical Pharmacokinetics - June 11, 2020 Category: Drugs & Pharmacology Source Type: research