Chalcones: As potent α-amylase enzyme inhibitors; synthesis, in vitro, and in silico studies.

CONCLUSION: Chalcone derivatives (1-17) were synthesized, characterized, and evaluated for their α-amylase inhibition. SAR revealed that electron donating groups in the phenyl ring have more influence on enzyme inhibition. However, to insight the participation of different substituents in the chalcones on the binding interactions with the α-amylase enzyme, in silico (computer simulation) molecular modeling analyses were carried out.
PMID: 32525781 [PubMed - as supplied by publisher]

Source: Medicinal Chemistry - June 9, 2020 Category: Chemistry Authors: Ali M, Khan M, Zaman K, Wadood A, Iqbal M, Alam A, Shah S, Ashfaq Ur Rehman, Yousaf M, Rafique R, Khan KM Tags: Med Chem Source Type: research