Identification of three circular RNA cargoes in serum exosomes as diagnostic biomarkers of non-small-cell lung cancer in the Chinese population

The recent discovery of circular RNAs (circRNAs) in serum exosomes has suggested a novel and potentially useful tool for cancer non-invasive diagnosis. However, there is yet, no substantial studies addressing this topic. RNA-seq analysis was performed between three pairs of non-small-cell lung cancer (NSCLC) patients and controls. The diagnostic values of exosomal circRNAs were assessed in a training set, validation set 1 and validation set 2. A total of 46 abnormally expressional circRNAs were identified.

Source: Journal of Molecular Diagnostics - June 10, 2020 Category: Pathology Authors: Jianfeng Xian, Wenpeng Su, Li Liu, Boqi Rao, Mingzhu Lin, Yinyi Feng, Fuman Qiu, Jinbin Chen, Qiang Zhou, Zhuxiang Zhao, Jiachun Lu, Lei Yang Tags: Regular Article Source Type: research