Diagnostic accuracy of intrathecal kappa free light chains compared with OCBs in MS
Conclusion
All evaluated KFLC metrics have excellent accuracy, and both KFLC intrathecal fraction and CSF KFLC/CSF albumin are at least as good as OCB in separating patients with MS from a control group.
Classification of evidence
This study provides Class III evidence that CSF KFLC accurately distinguishes patients with MS from healthy controls.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Duell, F., Evertsson, B., Al Nimer, F., Sandin, A., Olsson, D., Olsson, T., Khademi, M., Hietala, M. A., Piehl, F., Hansson, M. Tags: Diagnostic test assessment, Multiple sclerosis Article Source Type: research