Lack of Clinical Response to deep brain stimulation of the medial forebrain bundle in depression

Deep brain stimulation (DBS) is a promising treatment option for severe refractory major depressive disorder (MDD) [1, 2]. The most common neural targets for DBS in MDD are the subcallosal cingulate cortex (SCC) and the ventral capsule/ventral striatum (VC/VS) [3-5]. The long-term clinical response after DBS to these targets has been characterized as a gradual improvement in mood, with> 40% of patients reaching a responder status by 1 year [3, 4].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research