Physiologically-Based Pharmacokinetic Predictions of the Effect of Curcumin on Metabolism of Imatinib and Bosutinib: In Vitro and In Vivo Disconnect

ConclusionA PBPK model for curcumin in a SLN formulation was successfully developed. Although curcumin possesses a strongIn Vitro inhibitory activity towards CYP3A4 and CYP2C8 enzymes, its interactions with imatinib and bosutinib were unlikely to be of clinical importance due to curcumin ’s poor bioavailability.

http://link.springer.com/10.1007/s11095-020-02834-8

Source: Pharmaceutical Research - June 10, 2020 Category: Drugs & Pharmacology Source Type: research