Correlation between serum levels of endothelin-1 and disease severity in patients with neuromyelitis optica spectrum disorders.

CONCLUSION: ET-1 and IL-6 might exert pro-inflammatory effects in the pathogenesis of NMOSD, whereas IL-10 played an anti-inflammatory role in this process. ET-1 might be a potential biomarker for predicting the severity of NMOSD. However, the serum levels of ET-1 were not correlated with the changes of other cytokines/chemokines in patients with NMOSD. The involvement of ET-1 in the development of NMOSD needs to be further studied.
PMID: 32517881 [PubMed - in process]

Source: Immunobiology - April 30, 2020 Category: Allergy & Immunology Authors: Yi M, Liu MQ, Chou LS, Jiang SM, Zhang LJ, Huang CN, Wang N, Zhang QX, Yang L Tags: Immunobiology Source Type: research