Spermidine supplementation and voluntary activity differentially affect obesity-related structural changes in the mouse lung.

In conclusion, excess fat consumption induced alveolar capillary remodeling indicative of impaired perfusion and gas diffusion. Spermidine alleviated obesity-related endothelial alterations indicating a beneficial effect, whereas physical activity reduced lung volumes apparently by other, possibly systemic effects.
PMID: 32521164 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - June 9, 2020 Category: Cytology Authors: Ahrendt N, Steingrüber T, Rajces A, Lopez-Rodriguez E, Eisenberg T, Magnes C, Madeo F, Sedej S, Schmiedl A, Ochs M, Mühlfeld C, Schipke J Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research