Reduced Deformability of Stored Red Blood Cells is Associated with Generation of Extracellular Vesicles

Throughout storage, red blood cells (RBCs) undergo detrimental changes in viability and their ability to effectively transport oxygen. RBC storage lesions are mediated, in part, by a progressive loss of cell deformability, and associated with the release of extracellular vesicles (EVs). Accumulation of EVs during the storage of RBCs correlates with a decrease in RBC surface area to volume ratio. Similarly, the loss of RBC-deformability is associated with loss of RBC surface area to volume ratio.
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Tags: Short Report Source Type: research
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