Asiaticoside inhibits TGF- β1-induced mesothelial-mesenchymal transition and oxidative stress via the Nrf2/HO-1 signaling pathway in the human peritoneal mesothelial cell line HMrSV5.

Conclusions: Asiaticoside inhibited the TGF-β1-induced MMT and ROS via Nrf2 activation, thus protecting the peritoneal membrane and preventing PF.
PMID: 32514269 [PubMed - in process]

Source: Cellular and Molecular Biology Letters - June 11, 2020 Category: Biochemistry Authors: Zhao J, Shi J, Shan Y, Yu M, Zhu X, Zhu Y, Liu L, Sheng M Tags: Cell Mol Biol Lett Source Type: research