Clinicopathological factors associated with tumor-infiltrating lymphocyte reactivity in breast cancer

ConclusionTILs from approximately half the TNBC cases with NAC showed reactivity against autologous cancer cells. The proportion of PD-1+ T cells was higher in the reactive group. Adoptive TIL therapy combined with PD-1 inhibitors might be promising for TNBC patients with residual tumors after NAC.

http://link.springer.com/10.1007/s00262-020-02633-5

Source: Cancer Immunology, Immunotherapy - June 10, 2020 Category: Cancer & Oncology Source Type: research

Related Links:

A new depsidone from the lichen Usnea ceratina Arch.

Abstract Chemical investigation of the lichen Usnea ceratina Arch led to the isolation of five depsidones, including one new compound ceratinalone (1) along with four known compounds bailesidone (2), stictic acid (3), 8'-O-methylstictic acid (4) and 8'-O-ethylstictic acid (5). The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. Compounds 1 and 4 were evaluated the cytotoxic activity against HeLa (human epithelial carcinoma), NCI-H460 (human lung cancer), HepG2 (liver hepatocellular carcinoma), and MCF-7 (human breast cancer) cell lines, showing the m...

Source: Natural Product Research - October 9, 2020 Category: Biochemistry Authors: Bui VM, Duong TH, Chavasiri W, Nguyen KP, Huynh BL Tags: Nat Prod Res Source Type: research

ASAP Metabolic Effects of a Eucalyptus Bark Lipophilic Extract on Triple Negative Breast Cancer and Nontumor Breast Epithelial Cells

Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.0c00559

Source: Journal of Proteome Research - October 7, 2020 Category: Biochemistry Authors: A ̂ngela R. Guerra, Belinda I. G. Soares, Carmen S. R. Freire, Armando J. D. Silvestre, Maria F. Duarte, and Iola F. Duarte Source Type: research

MicroRNA-1297 downregulation inhibits breast cancer cell epithelial-mesenchymal transition and proliferation in a FA2H-dependent manner.

In conclusion, the present study indicated that miR-1297/FA2H might serve as a novel potential biomarker and therapeutic target for BC. PMID: 33014155 [PubMed]

Source: Oncology Letters - October 6, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

The Natural Alkaloid Piperlongumine Inhibits Metastatic Activity and Epithelial-to-Mesenchymal Transition of Triple-Negative Mammary Carcinoma Cells.

In this study, we determined the effect of low dose piperlongumine on the motility/invasive capacity and epithelial-to-mesenchymal transition (EMT) of MDA-MB-231 triple-negative breast cancer (TNBC) cells and the metastasis of 4T1 mouse mammary carcinoma cells. MTT assays measured the effect of piperlongumine on TNBC cell growth. Motility/invasiveness were determined by gap closure/transwell assays. Western blotting assessed ZEB1, Slug, and matrix metalloproteinase (MMP) 9 expression. Interleukin (IL) 6 was detected by ELISA. MMP2, E-cadherin, and miR-200c expression was determined by real-time quantitative polymerase chai...

Source: Nutrition and Cancer - October 4, 2020 Category: Cancer & Oncology Authors: Delaney LM, Farias N, Ghassemi Rad J, Fernando W, Annan H, Hoskin DW Tags: Nutr Cancer Source Type: research

Emodin reduces Breast Cancer Lung Metastasis by suppressing Macrophage-induced Breast Cancer Cell Epithelial-mesenchymal transition and Cancer Stem Cell formation

Conclusion: Natural compound emodin suppresses EMT and CSC formation of breast cancer cells by blocking TGF-β1-mediated crosstalk between TAMs and breast cancer cells. Our study provides evidence suggesting that emodin harbors the potential for clinical development as a new effective and safe agent to halt metastatic recurrence of breast cancer.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Qing Liu, Johnie Hodge, Junfeng Wang, Yuzhen Wang, Lianming Wang, Udai P. Singh, Yong Li, Yongzhong Yao, Dawei Wang, Walden Ai, Prakash Nagarkatti, Hexin Chen, Peisheng Xu, E. Angela Murphy, Daping Fan Tags: Research Paper Source Type: research

A feedforward circuit shaped by ECT2 and USP7 contributes to breast carcinogenesis

Conclusion: Our study uncovers a GEF-independent role of ECT2 in promoting survival of breast cancer cells, provides a molecular insight for the reciprocal regulation of ECT2 and USP7, and supports the pursuit of ECT2/USP7 as potential targets for breast cancer intervention.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Qi Zhang, Cheng Cao, Wenchen Gong, Kaiwen Bao, Qian Wang, Yuejiao Wang, Liyuan Bi, Shuai Ma, Jiao Zhao, Ling Liu, Shanshan Tian, Kai Zhang, Jie Yang, Zhi Yao, Nan Song, Lei Shi Tags: Research Paper Source Type: research

Loss of SIRT4 promotes the self-renewal of Breast Cancer Stem Cells

Conclusions: These results demonstrate that SIRT4 exerts its tumor-suppressive activity via modulating SIRT1 expression in breast cancer and provide a novel cross-talk between mitochondrial and nuclear sirtuins.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Lutao Du, Xiaoyan Liu, Yidan Ren, Juan Li, Peilong Li, Qinlian Jiao, Peng Meng, Fang Wang, Yuli Wang, Yun-shan Wang, Chuanxin Wang Tags: Research Paper Source Type: research

Role of ARID1A in epithelial ‑mesenchymal transition in breast cancer and its effect on cell sensitivity to 5‑FU.

Role of ARID1A in epithelial‑mesenchymal transition in breast cancer and its effect on cell sensitivity to 5‑FU. Int J Mol Med. 2020 Nov;46(5):1683-1694 Authors: Wang T, Gao X, Zhou K, Jiang T, Gao S, Liu P, Zuo X, Shi X Abstract The loss of function mutation of AT‑rich interactive domain 1A (ARID1A) often occurs in patients with breast cancer. It has been found that ARID1A knockout can enhance both the migratory activity of renal carcinoma cells and their sensitivity to therapeutic drugs by promoting epithelial-mesenchymal transition (EMT); however, its mechanisms of action in breast ...

Source: International Journal of Molecular Medicine - October 3, 2020 Category: Molecular Biology Authors: Wang T, Gao X, Zhou K, Jiang T, Gao S, Liu P, Zuo X, Shi X Tags: Int J Mol Med Source Type: research

Budlein A methylacrylate demonstrates potent activity against triple-negative breast cancer by targeting I κBα kinase and exportin-1.

In conclusion, this study provides evidence that co-inhibition of IKKβ and XPO-1 by BAM was effective against TNBC, demonstrating it as a representative new generation inhibitor with potential for TNBC treatment. PMID: 33022283 [PubMed - as supplied by publisher]

Source: Toxicology and Applied Pharmacology - October 2, 2020 Category: Toxicology Authors: Wang XZ, Feng Y, Han YF, Bian Y, Liang J, Wen HM, Wu H Tags: Toxicol Appl Pharmacol Source Type: research

Performance of a clinical and imaging-based multivariate model as decision support tool to help save unnecessary surgeries for high-risk breast lesions

AbstractPurposeTo investigate the performance of an imaging and biopsy parameters-based multivariate model in decreasing unnecessary surgeries for high-risk breast lesions.MethodsIn an IRB-approved study, we retrospectively reviewed all high-risk lesions (HRL) identified at imaging-guided biopsy in our institution between July 1, 2014-July 1, 2017. Lesions were categorized high-risk-I (HR-I = atypical ductal hyperplasia, atypical lobular hyperplasia, lobular carcinoma in situ and atypical papillary lesion) and II (HR-II = Flat epithelial atypia, radial scar, benign papilloma). Patient risk fact...

Source: Breast Cancer Research and Treatment - October 2, 2020 Category: Cancer & Oncology Source Type: research