Mesenchymal Stem Cells: A New Generation of Therapeutic Agent Vehicles in Gene Therapy.

Mesenchymal Stem Cells: A New Generation of Therapeutic Agent Vehicles in Gene Therapy. Curr Gene Ther. 2020 Jun 07;: Authors: Gharbavi M, Sharafi A, Ghanbarzadeh S Abstract In recent years, mesenchymal stem cells (MSCs) as a new tool for therapeutic gene delivery in clinics have attracted much attention. Its advantages contain longer lifespan, better isolation, and higher transfection efficiency and proliferation rate. MSCs are the preferred approach for cell-based therapies because of their in vitro self-renewal capacity, migrating especially to tumor tissues, as well as anti-inflammatory and immunomodulatory properties. Therefore, they have considerable efficiency in genetic engineering for future clinical applications in cancer gene therapy and other diseases. For improving in therapeutic efficiency, targeted therapy of cancers can be achieved through sustained release of therapeutic agents and functional gene expression induction to the intended tissues. The development of a new vector in gene therapy can improve the durability of transgene expression. Also, the safety of the vector if administered systemically may resolve several problems, such as durability of expression and the host immune response. Currently, MSCs are prominent candidates as cell vehicles for both preclinical and clinical trials due to the secretion of therapeutic agents in several cancers. In the present study, we discuss the status of gene therapy in both ...
Source: Current Gene Therapy - Category: Genetics & Stem Cells Authors: Tags: Curr Gene Ther Source Type: research