Clinimetric evaluation of muscle function tests for individuals with cystic fibrosis: A systematic review

Cystic fibrosis (CF) is a genetic multisystemic disease caused by a mutation of the CFTR (Cystic Fibrosis Transmembrane Regulator) gene [1]. CF is associated with a progressive decline in lung function, but it also impacts on systemic functions, including muscle function [2]. Quadriceps strength (along with fat-free mass) is strongly related to reduced maximal aerobic capacity (measured by cardio-pulmonary exercise testing), which leads to a progressive reduction of quality of life and an increased rate of mortality [3 –5].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Source Type: research