Perivascular fibro-adipogenic progenitor tracing during post-traumatic osteoarthritis.
Perivascular mural cells surround capillaries and microvessels, and have diverse regenerative or fibrotic functions after tissue injury. Subsynovial fibrosis is a well known pathologic feature of osteoarthritis, yet transgenic animals to visualize perivascular cell contribution to fibrosis during arthritic changes have not been developed. Here, inducible Pdgfra-CreERT2 reporter mice were subjected to joint destabilization surgery in order to induce arthritic changes, and cell lineage traced over an 8 week period with a focus on the joint-associated fat pad.
Source: American Journal of Pathology - Category: Pathology Authors: Takashi Sono, Ching-Yun Hsu, Yiyun Wang, Jiajia Xu, Masnsen Cherief, Simone Marini, Amanda K. Huber, Sarah Miller, Bruno P éault, Benjamin Levi, Aaron W. James Tags: Regular Article Source Type: research