Severe paradoxical disease activation following alemtuzumab treatment for multiple sclerosis

A 39-year-old right-handed agricultural service engineer developed rapidly evolving severe relapsing-remitting multiple sclerosis (MS). MRI showed multiple T2 hyperintensities throughout his neuroaxis (figure, A). Several lesions showed restricted diffusion, and 2 enhanced. He received steroids for each relapse, making a full recovery (Expanded Disability Status Score [EDSS] 0).

Source: Neurology Neuroimmunology and Neuroinflammation - June 9, 2020 Category: Neurology Authors: Brannigan, J., Jones, J. L., Stacpoole, S. R. L. Tags: Autoimmune diseases, Encephalitis, Multiple sclerosis, Acute disseminated encephalomyelitis Clinical/Scientific Notes Source Type: research