A GM-CSF-neuroantigen tolerogenic vaccine elicits inefficient antigen recognition events below the CD40L triggering threshold to expand CD4+ CD25+ FOXP3+ Tregs that inhibit experimental autoimmune encephalomyelitis (EAE)
Tolerogenic vaccines represent antigen-specific interventions designed to re-establish self-tolerance and thereby alleviate autoimmune diseases, which collectively comprise over 100 chronic inflammatory diseas...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Cody D. Moorman, Alexander G. Bastian, Kayla B. DeOca and Mark D. Mannie Tags: Research Source Type: research