Extrasynaptic CaMKII α is involved in the antidepressant effects of ketamine by downregulating GluN2B receptors in an LPS-induced depression model
A subanesthetic dose of ketamine provides rapid and effective antidepressant effects, but the molecular mechanism remains elusive. It has been reported that overactivation of extrasynaptic GluN2B receptors is ...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Xiao-Hui Tang, Guang-Fen Zhang, Ning Xu, Gui-Fang Duan, Min Jia, Ru Liu, Zhi-Qiang Zhou and Jian-Jun Yang Tags: Research Source Type: research