Narrative Summary of Recently Published Literature on Intravenous Ibuprofen.

Narrative Summary of Recently Published Literature on Intravenous Ibuprofen. Clin Ther. 2020 Jun 03;: Authors: Southworth SR, Sellers JA Abstract PURPOSE: This is a narrative review of the published literature on IV ibuprofen (IVIB) as one of the drugs used in multimodal pain management in inpatients and outpatients pre- and postoperatively and for nonsurgical pain or fever. METHODS: The efficacy, concurrent opioid use, pharmacokinetic properties, tolerability, stress response, and postoperative recovery with IVIB, which were investigated in 9 clinical studies, are presented in this narrative review. In total, 344 adult patients and healthy volunteers were included in these 9 studies; 200 of these subjects received IVIB, and the remaining 144 received either placebo or a comparator medication. FINDINGS: The plasma ibuprofen level with IVIB was twice that with oral ibuprofen, and patients experienced less postoperative pain, decreased opioid use, improved quality of recovery, and reduced postsurgical fatigue and surgical stress response, and used less over-the-counter medication. IMPLICATIONS: Overall, preemptive IVIB should be considered in the analgesic regimen for the management of pre- and postoperative pain, as it has a favorable safety profile, with fewer associated adverse events and serious adverse events, significantly lower levels of perioperative cytokines and catecholamines, and improved peri- and ...
Source: Clinical Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Ther Source Type: research