Galectin-3 inhibition attenuates doxorubicin-induced cardiac dysfunction by upregulating the expression of peroxiredoxin-4.

In conclusion, Gal-3 mediated Dox-induced cardiotoxicity and Gal-3 inhibition attenuated Dox-induced cardiac dysfunction by upregulating the expression of Prx-4 to reduce myocardial oxidative stress. PMID: 32516552 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32516552?dopt=Abstract

Source: Canadian Journal of Physiology and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Authors: Tian Y, Lv W, Lu C, Jiang Y, Yang X, Song M Tags: Can J Physiol Pharmacol Source Type: research