Levetiracetam induction of theta frequency oscillations in rodent hippocampus in vitro.

Levetiracetam induction of theta frequency oscillations in rodent hippocampus in vitro. Can J Physiol Pharmacol. 2020 Jun 09;: Authors: Xing H, Xu S, Xie X, Wang Y, Lu C, Han X Abstract Levetiracetam(LEV) has been demonstrated to improve cognitive function. Hippocampal theta rhythm (4-12 Hz) is associated with a variety of cognitively related behaviors, such as exploration in both humans and animal models. We investigated the effects of LEV on the theta rhythm in the rat hippocampal CA3 in hippocampal slices in vitro. We found that LEV increased the theta power in a dose-dependent manner. The increase in theta power can be blocked by GABA<sub>A</sub> receptor(GABA<sub>A</sub>R) or NMDA receptor(NMDAR) antagonists but not by AMPA receptor antagonist, indicating the involvement of GABA<sub>A</sub>R and NMDAR in the induction of theta activity. Interestingly, LEV enhancement of theta power can be also blocked by taurine or GABA-A agonist THIP, indicating that LEV induction of theta may be related to the indirect boosting of GABA action via reduction of extrasynaptic GABA<sub>A</sub>R activation. Furthermore, the increased theta power can be partially reduced by mACh receptor(mAChR) antagonist atropine but not by nACh receptor antagonists, suggesting that mAChR activation provides excitatory input into local network responsible for LEV induced theta. Our study demonstrated that LEV induced ...
Source: Canadian Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Can J Physiol Pharmacol Source Type: research