Fecal microbiota transplantation from high caloric-fed donors alters glucose metabolism in recipient mice, independently of adiposity or exercise status.

Fecal microbiota transplantation from high caloric-fed donors alters glucose metabolism in recipient mice, independently of adiposity or exercise status. Am J Physiol Endocrinol Metab. 2020 Jun 09;: Authors: Zoll J, Read MR, Heywood SE, Estevez E, Marshall JP, Kammoun HL, Allen TL, Holmes AJ, Febbraio MA, Henstridge DC Abstract Studies suggest gut microbiota contributes to the development of obesity and the metabolic syndrome. Exercise alters microbiota composition and diversity and is protective of these maladies. We tested whether the protective metabolic effects of exercise are mediated through fecal components through assessment of body composition and metabolism in recipients of fecal microbiota transplantation (FMT) from exercise-trained (ET) mice fed normal or high energy diets. Donor C57BL/6J mice were fed a chow or high fat, high sucrose (HFHS) diet for 4wk to induce obesity and glucose intolerance. Mice were divided into sedentary (Sed) or ET groups [6wk treadmill-based ET] while maintaining their diets, resulting in four donor groups; chow sedentary (NC-Sed) or ET (NC-ET) and HFHS sedentary (HFHS-Sed) or ET (HFHS-ET). Chow-fed recipient mice were gavaged with feces from the respective donor groups weekly, creating four groups (NC-Sed-R, NC-ET-R, HFHS-Sed-R, HFHS-ET-R) and body composition and metabolism assessed. The HFHS diet led to glucose intolerance and obesity in the donors, while exercise training (ET) restrained adi...
Source: Am J Physiol Endocri... - Category: Endocrinology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research