Diagnostic performance of direct immunofluorescence microscopy studies by biopsy sites in autoimmune subepidermal blistering dermatoses: a prospective study.

Diagnostic performance of direct immunofluorescence microscopy studies by biopsy sites in autoimmune subepidermal blistering dermatoses: a prospective study. Br J Dermatol. 2020 Jun 07;: Authors: Haefliger S, Sitaru S, Cazzaniga S, Rammlmair A, Feldmeyer L, Horn MP, Borradori L Abstract The diagnosis of autoimmune subepidermal blistering diseases, such as bullous pemphigoid (BP), critically relies on the detection of tissue-bound immunoreactants along the epidermal basement membrane by direct immunofluorescence microscopy (DIF) studies of skin biopsy specimens obtained from perilesional skin 1,2 . However, there was surprisingly no consensus among international experts about the definition of perilesional skin 1 . The latter was considered as either normal appearing skin surrounding an inflamed area or erythematous skin adjacent to a blister. PMID: 32506435 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research