The mid-life transition and the risk of cardiovascular disease and cancer ii: strategies to maximize quality of life and limit dysfunction and disease

Chronic dysfunction, disabilities and complex diseases such as cardiovascular disease, Diabetes Mellitus Type 2, osteoporosis and certain cancers among other burdens emerge and accelerate in midlife women. Previously in Part l we have described clinical and laboratory research findings which more readily explain and clarify the underlying pathogenetic mechanisms driving these clinical burdens. Included were new findings on how in particular visceral obesity and the emergence and acceleration of various components of the Metabolic Syndrome – glucotoxicity, lipotoxicity and a chronic systemic inflammatory state abetted by loss of ovarian production of estradiol and the inevitable inroads of aging generate this spectrum of clinical problems.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Expert Review Source Type: research