Is pasireotide-induced diabetes mellitus predictable? A pilot study on the effect of a single dose of pasireotide on glucose homeostasis

ConclusionsPAS was rapidly able to suppress insulin and incretin secretion, with a subsequent rise in glucose levels into the diabetic range. It also induced a significant inhibition of glucagon production. The patients at higher risk of DM during PAS therapy were those with higher glucagon levels, HbA1c  >  34.5 mmol/mol, and a glucose peak after PAS administration >  9 mmol/L. CD patients with these features given PAS therapy should therefore be monitored more carefully.
Source: Pituitary - Category: Endocrinology Source Type: research