Pyoluteorin induces cell cycle arrest and apoptosis in human triple ‐negative breast cancer cells MDA‐MB‐231

ConclusionOur studies revealed that pyoluteorin had potent proliferation inhibition against MDA ‐MB‐231 cells through arresting cell cycle at G2/M phase and inducing caspase ‐3‐dependent apoptosis by mitochondrial pathway, implying that pyoluteorin may be a potential lead compound for drug discovery of human triple‐negative breast cancer.

Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Authors: Ting Ding, Luo ‐Jie Yang, Wei‐Dong Zhang, Yun‐Heng Shen Tags: Research Paper Source Type: research