What are the consequences of Methylphenidate exposure for maternally separated rats?

What are the consequences of Methylphenidate exposure for maternally separated rats? Int J Dev Neurosci. 2020 Jun 08;: Authors: Mohtashami Borzadaran F, Esmaeilpour K, Joushi S, Rajizadeh MA, Sheibani V, Ur Rehman N Abstract Methylphenidate (MPH) abuse is prevalent among youth. Drug abuse results in pain perception. We sought to investigate whether Maternal separation (MS) prone to MPH addiction. The next question was whether MPH abusers with MS differ in pain perception. We investigated the impact of MS on addiction and drug reward as well as pain perception following 5 days of MPH injection in males and females rats. Initially, rats underwent MS protocol of 3 hours daily for 21 days. Conditioned place preference (CPP) test was an attempt to investigate whether MS rats experience more reward with MPH. The protocol consisted of 10 minutes habituation on day1, conditioning on day2-day6 (5mg per kg MPH injection in drug compartment and saline in saline compartment with 4 hours gap between injections) and 10 minutes test on day7. Furthermore, using another group, differences in pain perception were investigated after 5 days of daily MPH injection with 5mg per kg. Sensory pain sensitivity was tested on PND 39 using tail flick and hotplate in MS and control groups with and without MPH exposure. Results indicated that female rats are equally prone to addiction in CPP. On the other hand, MS males experience a higher reward in CPP. In tail f...
Source: International Journal of Developmental Neuroscience - Category: Neuroscience Authors: Tags: Int J Dev Neurosci Source Type: research